Endogenous retroviruses in amyotrophic lateral sclerosis

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Retroviruses and amyotrophic lateral sclerosis.

Amyotrophic lateral sclerosis (ALS) is a progressive, invariably fatal neurologic disorder resulting from upper and lower motor neuron degeneration, which typically develops during the sixth or seventh decade of life, and is diagnosed based on standard clinical criteria. Its underlying cause remains undetermined. The disease may occur with increased frequency within certain families, often in a...

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Endogenous retroviruses and multiple sclerosis.

Endogenous retroviruses are normal constituents in vertebrate genomes. They have been associated with various diseases of presumed autoimmune etiology. However, conclusive evidence of their significance as susceptibility factors in these diseases is still lacking. In our laboratory we have focused attention upon endogenous retroviruses as candidate genes in multiple sclerosis. In this communica...

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Amyotrophic Lateral Sclerosis

Touch MEdical MEdia 53 Fasciculation, which is observed in various peripheral motor neuron disorders, is most frequently found in nonprogressive benign fasciculation syndrome (BFS). Patients with BFS never exhibit muscle atrophy or pathologic weakness and not all such patients visit hospitals; therefore, the prevalence and characteristics of BFS still need to be established. However, among the ...

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[Amyotrophic lateral sclerosis].

Amyotrophic lateral sclerosis (ALS) is a progressive, degenerative disease of the motor system characterized by signs and symptoms of upper and lower motor dysfunction. This results in the presence of focal amyotrophies and pareses affecting voluntary muscles. Patients die after a few years, in most cases by respiratory failure. ALS is the most frequent motor neuron disease; however, its etiolo...

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ژورنال

عنوان ژورنال: Future Virology

سال: 2016

ISSN: 1746-0794,1746-0808

DOI: 10.2217/fvl-2016-0038